Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3965810 | Journal of Reproductive Immunology | 2011 | 10 Pages |
Abstract
In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA × DBA/2 and CBA × BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss.
Keywords
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Authors
Gérard Chaouat, Nathalie Rodde, Marie Petitbarat, Roberta Bulla, Mona Rahmati, Sylvie Dubanchet, Sandrine Zourbas, Isabelle Bataillon, Nathalie Coqué, Benoit Hennuy, Jacques Martal, Carine Munaut, Julie Aubert, Valérie Sérazin, Thiel Steffen,