Recurrent miscarriage

Miscarriage is one of the most common complications of pregnancy. Fifteen percent of clinically recognized pregnancies end in miscarriage. The major cause of spontaneous miscarriage is genetic or developmental abnormalities of the foetus. Recurrent miscarriage occurs in 3% of the population and has been associated with thrombophillias, infections and endocrine, anatomical and immune factors. Treatments to prevent miscarriage remain largely untested by randomized controlled trials (RCTs). The results of the limited available evidence indicate that the wide use of empirical treatments has led to minimal benefit for both patients and health care providers. This article is therefore designed to enhance critical thinking and improve clinical skills in an area with extensive and contradictory literature.