Article ID Journal Published Year Pages File Type
3971284 Reproductive BioMedicine Online 2011 4 Pages PDF
Abstract

Genetic knockout studies in the mouse model first revealed the essential role of zygotically derived Cdx2 transcription factor during the later stages of blastocyst formation, characterized by a lack of functioning trophectoderm. However, the extent to which the potential provision of maternally derived Cdx2 affects preimplantation development has proved much less simple to address. Within the last year, two reports have been published arguing for and against a distinct functional role for maternal Cdx2. This commentary aims to discuss the approaches, results and interpretations of both studies in an attempt to resolve the apparent conflict and to constructively advance collective understanding.

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Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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