Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3974114 | Seminars in Fetal and Neonatal Medicine | 2014 | 8 Pages |
Abstract
SummaryThis review focuses on the emerging field of non-surgical in-utero therapies in the management of fetal pulmonary hypoplasia and pulmonary hypertension associated with congenital diaphragmatic hernia (CDH). These experimental approaches include pharmacologic as well as stem-cell-based strategies. Current barriers of non-surgical therapies toward clinical translation are emphasized. As the severity of CDH will likely influence the efficacy of any in-utero therapy, the current status of prenatal imaging and the role of novel biomarkers, especially those related to fetal inflammation, are also reviewed.
Keywords
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Authors
Cerine Jeanty, Shaun M. Kunisaki, Tippi C. MacKenzie,