Relationship between hypothyroidism and the incidence of gestational diabetes: A meta-analysis

ObjectivesHypothyroidism disorders and gestational diabetes are among the most common endocrinopathies during pregnancy. We conducted a meta-analysis to investigate whether hypothyroidism in pregnancy is associated with gestational diabetes risk.Materials and methodsPublished literature from PubMed and EMBASE were searched for eligible publications. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a fixed- or random-effects model.ResultsSeven articles described the relationship between hypothyroidism and risk of gestational diabetes. This meta-analysis revealed that overt hypothyroidism was associated with an increased risk of gestational diabetes (OR 1.892, 95% CI 1.679–2.132, p < 0.001). The relative risk of gestational diabetes was also increased in subclinical hypothyroidism, with the OR of 1.558 (95% CI 1.292–1.877, p < 0.001). There was no evidence of significant association between hypothyroxinemia and risk of gestational diabetes (OR 1.394, 95% CI 0.753–2.580, p = 0.291). The OR for all of the hypothyroidism was 1.749 (95% CI 1.586–1.928, p < 0.001), and an association was found.ConclusionResults of this meta-analysis indicate that hypothyroidism may be a risk factor for gestational diabetes.