Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3978545 | Bulletin du Cancer | 2015 | 8 Pages |
Abstract
Oral anticancer agents and particularly kinase inhibitors are subject to pharmacokinetic drug interactions in relation to absorption and elimination phases. Interacting factors are food, fruit juices, cigarette smoke, acid-reducing agents and inducers/inhibitors. Some anticancer agents are inducers and/or inhibitors and can also perpetrate drug interactions. This review emphasizes the mechanisms of pharmacokinetic drug interactions involving oral anticancer agents.
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Authors
Dominique Levêque, Céline Duval, Charlotte Poulat, Benjamin Palas, Anne El Aatmani, Anne Dory, Guillaume Becker, Bénédicte Gourieux,