| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3979040 | Bulletin du Cancer | 2010 | 18 Pages |
Abstract
Advances in chromosome dynamics have increased our understanding of the significant role of telomeres and telomerase in cancer. Telomerase is expressed in almost all cancer cells but is inactive in most normal somatic cells. Therefore, telomerase is an important target for the design of therapeutic agents that might have minimal side effects. Herein, we evaluate current approaches to telomerase/telomere-targeted therapy, discuss the benefits and disadvantages, and speculate on the future direction of telomerase inhibitors as cancer therapeutics.
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Authors
Souiden Y., Bouraoui A., Chaieb K., Mahdouani K.,