Article ID Journal Published Year Pages File Type
3979126 Bulletin du Cancer 2010 10 Pages PDF
Abstract
Nasopharyngeal carcinomas (NPC) are predominantly of undifferentiated type (UCNT or undifferentiated carcinoma of nasopharyngeal type), rare (< 1/100000) and sporadic in occidental countries, but endemic in the Mediterranean area of intermediate incidence (2 to 10/100000) and highly frequent (> 10/100000) in South East Asia. NPC staging is based on TNM UICC 2002 that has a prognostic and therapeutic orientation impact. Irradiation of the primitive tumor and its extensions remains the standard loco-regional treatment. The recent introduction of primary and concomitant chemotherapy leads to an improvement in terms of overall and disease-free survival, specially for for high-risk-patients (T3-4 and N2-3 disease). Prognosis remain linked to T, N, histologic type and quality of response to chemotherapy and radiotherapy.
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Health Sciences Medicine and Dentistry Oncology
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