Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3979417 | Bulletin du Cancer | 2010 | 9 Pages |
Abstract
The epithelial-mesenchymal transition (EMT) is a morphogenetic program that converts epithelial into mesenchymal cells during the embryonic development. This mechanism is frequently reactivated during tumor progression and provides cells with motility and invasive capabilities favoring the metastatic dissemination from epithelial tumors. Various EMT-inducing transcription factors, such as the TWIST proteins, were also shown to inhibit oncogene-induced failsafe programs (senescence and apoptosis), thereby promoting the progression from benign to malignant stages. Altogether, these observations suggest that EMT could play an important role in favoring both tumor development and metastatic dissemination.
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Authors
S. Ansieau, C. Caron de Fxromentel, J. Bastid, A.-P. Morel, A. Puisieux,