| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3981382 | Clinical Radiology | 2016 | 9 Pages |
•Recommended approach for staging lymphoma is 18F-FDG-PET with CT and BM biopsy.•Wb-MRI-DWI is a new alternative technique to conventional radiation-based imaging.•Wb-MRI-DWI is both sensitive and specific in staging malignant lymphoma.
AimTo compare the accuracy of whole-body magnetic resonance imaging (Wb-MRI) with diffusion-weighted imaging (DWI) to that of contrast-enhanced computed tomography (CE-CT) and 2-[18F]-fluoro-2-deoxy-d-glucose (18F-FDG) positron-emission tomography co-registered with low dose-CT (PET-CT) in defining lymphoma disease stage.Materials and methodsFrom February 2010 to May 2014, 41 lymphoma patients underwent Wb-MRI-DWI, CE-CT, and 18F-FDG PET-CT. Histological subtypes included aggressive B-cell (n=11), follicular (n=13), mantle cell (n=3), and Hodgkin's (n=14) lymphoma. To compare the procedures, the reference standard (RS) assessment was defined by combining the results from 18F-FDG PET-CT, CE-CT, and bone marrow (BM) histology, modifications after therapy, and histological re-assessments of uncertain lesions.ResultsAmong 1025 nodal sites, 217 had disease involvement according to the RS. CE-CT yielded 23 false-negative and 11 false-positive errors. Wb-MRI-DWI failed to recognise 17 localisations and had six false-positive errors; 18F-FDG PET-CT had no errors. Among 458 extranodal sites, 37 were positive according to the RS. 18F-FDG PET-CT yielded four false-negative and two false-positive results. CE-CT yielded 17 false-negative errors. Wb-MRI-DWI yielded a single false-negative error. Wb-MRI-DWI was the most reliable imaging technique for BM evaluation. Considering each procedure alone, the final stage would have been missed in four cases using 18F-FDG PET-CT, 12 cases using CE-CT, and none using Wb-MRI-DWI.ConclusionThe present data support Wb-MRI-DWI as a sensitive and specific imaging technique for lymphoma evaluation, supporting its use in place of CE-CT for staging.
