Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3985178 | European Journal of Surgical Oncology (EJSO) | 2014 | 8 Pages |
Abstract
PurposeThe clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens.MethodsVEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters.ResultsIn the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis.ConclusionsAlthough frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.
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Authors
E. Lastraioli, L. Boni, M.R. Romoli, S. Crescioli, A. Taddei, S. Beghelli, A. Tomezzoli, C. Vindigni, L. Saragoni, L. Messerini, M. Bernini, L. Bencini, E. Giommoni, G. Freschi, F. Di Costanzo, A. Scarpa, P. Morgagni, M. Farsi, F. Roviello,