Human papillomavirus type 18-associated cervical and lung mixed adenoneuroendocrine carcinoma

Human papillomavirus (HPV) is associated with neuroendocrine carcinoma of the cervix and lung. However, these two uncommon cancers rarely occur in a single patient, especially with the same HPV type. We herein present a 65-year-old non-smoker female who developed mixed adenoneuroendocrine carcinoma of the lung with lymph node, brain and adrenal gland metastases 6 years after the diagnosis of stage IA1 cervical mixed adenoneuroendocrine carcinoma. The patient's brain, lung and previous cervix specimens were identically HPV type 18 positive. To our knowledge, this is the first report of a patient with the same HPV type associated mixed adenoneuroendocrine carcinoma in different sites.