| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3988903 | Journal of the Egyptian National Cancer Institute | 2016 | 5 Pages |
Aim of workTo evaluate the sensitivity (Se), specificity (Sp), and predictive values (PV) of PET scan during management of pediatric mature B cell non-Hodgkin’s lymphoma (NHL) in comparison with conventional computed tomography (CT) scan.Patients and methodsA retrospective study enrolled on pediatric NHL patients at Children Cancer Hospital Egypt (CCHE) during the period from July 2007 to the end of June 2013.ResultsFor 115 pediatric patients diagnosed with mature B cell NHL, 152 PET and 152 CT scans were done simultaneously. Median age was 5.7 years. They were 85 males (74%) and 30 females (26%). One hundred twenty six scans (82.9%) were done for 100 (87%) Burkitt lymphoma (BL) patients, while 26 scans (17.1%) were done for 15 (13.0%) patients with diffuse large B cell NHL (DLBC). Nineteen examination (12.5%) were done before starting chemotherapy (group 1), 107 (70.3%) at time of evaluation (group 2), and 26 (17.1%) during follow up (group C). Overall sensitivity was 91.6% for PET and 70.0% for conventional CT (p = 0.02). Specificity was 84.1% for PET and 58.9% for CT (p < 0.001). Positive predictive value (PPV) for PET was 50%, while was 22% for CT scan (p < 0.001). Negative predictive value (NPV) for PET was 98%, and 92% for CT (p = 0.01).ConclusionPET scan is significantly more sensitive than conventional CT in the management of aggressive pediatric mature B cell NHL. PET negativity is an excellent indicator of tumor response.
