Article ID Journal Published Year Pages File Type
3989415 Journal of Thoracic Oncology 2016 5 Pages PDF
Abstract

IntroductionCiliated muconodular papillary tumors (CMPTs) are recently characterized, rare peripheral nodules of the lung. These small tumors are histologically comprised of a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, and consistently follow a benign clinical course. However, the histogenesis of CMPTs remains uncertain.MethodsWe performed detailed genomic analyses of 10 archived CMPT cases, using next-generation sequencing and high-resolution melting analysis.ResultsMutations were identified in eight of the 10 cases (80%); four cases harbored the BRAF-V600E mutation, one case harbored the BRAF-G606R mutation, and three cases harbored deletions in exon 19 of EGFR. All of the deletions in EGFR were of the E746-T751/S752V subtype.ConclusionsThe high prevalence of driver gene mutations in CMPTs supports the notion that these lesions are neoplastic rather than reactive or metaplastic.

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