Observer Variability in Mesothelioma Tumor Thickness Measurements: Defining Minimally Measurable Lesions

This study has implications for the definition of minimally measurable tumor adopted by clinical trial and staging protocols. Although the statistical findings suggest that a reduction in “minimally measurable disease” from 10 mm to 5 or 7.5 mm might be warranted, clinical factors may ultimately dictate the most appropriate definition.