Utility and validation of biomechanical deformable image registration in low-contrast images

Biomechanical registration accurately predicted the deformed dose distribution measured in a deformable dosimeter, whereas previously, evaluations of a commercial intensity-based algorithm demonstrated substantial errors. The addition of biomechanical algorithms to the collection of adaptive radiation therapy tools would be valuable for dose accumulation, particularly in feature-poor images such as cone beam CT and organs such as the liver.