Carcinoma anficrino de glándula mamaria. Reporte de un caso inusual

Amphicrine tumours of the mammary gland are very rare dual lesions with epithelial and neuroendocrine differentiation in the same cell. We report the case of a woman with a mass in the right breast. The histopathology study showed a malignant tumour formed by small cells inter-mixed with some cells with a signet ring appearance. The use of antibodies showed immunoreactivity for epithelial and neuroendocrine markers in the malignant cells. These characteristics enable the diagnosis of an amphicrine tumour, based on the expression of epithelial and neuroendocrine markers in the same cell. The differential diagnosis must be made with collision tumours or with metastasis. The rigorous interpretation of the immunohistochemistry in the malignant cells in an amphicrine tumour is useful in order to distinguish this tumour from other diseases with similar morphological characteristics.