| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4000170 | Urologic Oncology: Seminars and Original Investigations | 2013 | 6 Pages |
Abstract
BFA is capable of attenuating androgenic regulation in LNCaP cells such as androgen-stimulated PSA synthesis/secretion and cell growth. This BFA-blocked androgen action appears to be primarily attributed to severe inactivation of AR with BFA because AR is a crucial factor for relaying androgenic messages (to DNA). Therefore, BFA could be considered a promising agent for a more effective treatment of hormone-dependent prostate cancer.
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Authors
Bobby M.D., Andrew I. M.D., David M.D., Muhammad S. M.D., Sensuke Ph.D.,