Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4000438 | Urologic Oncology: Seminars and Original Investigations | 2012 | 7 Pages |
Abstract
We found that KAI1 expression in bladder cancer cell lines is related to a poor invasive potential and expression of latent MMP-2 but not MMP-9. These results are unexpected given other studies showing high levels of MMP-2 and MMP-9 protein expression in patients with invasive bladder cancer. This may reflect differences in the regulation and secretion of MMP-2 and MMP-9 in vitro compared with the in vivo situation, where tumor cells interact with the surrounding environment.
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Authors
JingJing B.Med.Sc.Hon., Michele C. Ph.D., Alexandra B.Sc., Mila B.Sc., Pamela J. Ph.D., Paul Ph.D.,