| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4005481 | American Journal of Ophthalmology | 2006 | 7 Pages |
Abstract
A transient increase in IOP to 100 cm H2O causes death of RGCs in rats. A single immunization with Cop-1 or daily injections of brimonidine protected up to 50% of potentially doomed RGCs from IOP-induced death, suggesting that not all of the cell death in the untreated model results from the IOP insult directly, but that some of it is caused by insult-induced environmental cytotoxicity, which is unrelated to glutamate toxicity or at least to NMDA receptors. These findings can be applied immediately as a basis for acute glaucoma therapy.
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Authors
Guy J. MD, Sharon MD, Eyal MD, Mordechai MD,