| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4013906 | Journal of American Association for Pediatric Ophthalmology and Strabismus | 2012 | 5 Pages |
PurposeTo compare long-term outcomes of botulinum toxin A injection with incisional surgery for the management of infantile esotropia.Subjects and MethodsMedical records of infants <24 months treated for esotropia with either botulinum toxin injection (botulinum group) or bilateral medial rectus muscle recessions (surgery group) were reviewed. Minimum follow-up was 48 months, and patients with accommodative esotropia or inferior oblique muscle overaction were excluded. Success was defined as alignment with 10Δ of orthophoria without surgery (botulinum group) or without reoperation (surgery group) and compared by the use of an adjusted odds ratio (aOR).ResultsThe record review identified a total of 51 patients, with 25 in the botulinum group and 26 in the surgery group. Median pretreatment deviation was similar in the botulinum and surgery groups (40Δ vs 45Δ; P = 0.37), but median age at treatment was earlier in the botulinum group (10 vs 12.5 months; P = 0.01). The mean number of injections in successfully treated botulinum group patients was 1.4. The success rate was similar in the botulinum (68%) and surgery (77%) groups (aOR = 0.87, P = 0.87). The median follow-up time was longer in the botulinum group (84 vs 75 months; P = 0.02). Gross stereopsis was demonstrable in 10 of 15 patients in the botulinum group and 9 of 13 in the surgery group (aOR = 3.6, P = 0.46).ConclusionsThere was no difference in binocular alignment with botulinum toxin versus surgical treatment. Botulinum toxin injection may be considered a primary treatment for infantile esotropia.
