Comparison of in vitro safety profiles of vancomycin and cefuroxime on human corneal endothelial cells for intracameral use

These data suggest a dose-dependent toxicity of cefuroxime and vancomycin on HCECs in vitro with a narrow range of safety. Although the clinically used concentrations seem to be safe, slightly higher concentrations might induce irreversible cell death and thus should be avoided.