| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4019448 | Journal of Cataract & Refractive Surgery | 2008 | 8 Pages |
Abstract
Tamsulosin was more effective than alfuzosin at blocking adrenergic contraction of the iris dilator muscle in pigmented rabbits. Both drugs were less potent in the iris than in the prostate, which suggests that an additional iris receptor could be involved. If valid in humans, our results suggest that attainable plasma concentrations of tamsulosin are able to antagonize iris dilator smooth muscle contraction, whereas those of alfuzosin are not. This could explain the higher frequency of intraoperative floppy-iris syndrome in patients treated with tamsulosin than with alfuzosin.
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Authors
Stefano PhD, David F. MD, Moez PhD, Alain VD, Philippe PhD,