Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4025868 | Ophthalmology | 2015 | 10 Pages |
Abstract
The pathogenic mechanisms of the 2 forms of dry eye give an account for the different MMP9 and TG2 expressions in the 2 groups of patients. The higher expression in SS is determined by the direct autoimmune insult to the ocular surface epithelia, whereas in MGD patients, with an epithelial damage due to an unbalanced tear secretion, the molecules expression is significantly lower, although higher than in controls. The corticosteroid treatment induced a reduction of both molecules, although higher in SS than in MGD, because of its direct inhibitory effect on inflammation.
Keywords
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Ophthalmology
Authors
Pasquale MD, PhD, M'Hammed PhD, Laura MD, PhD, Elisa MD, PhD, Margherita Serena MD, Anna Maria MD, PhD, Maria Grazia PhD, Antonina MD, Domenico MD,