| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4026003 | Ophthalmology | 2015 | 9 Pages |
Abstract
Chronic CSC is associated with genetic variants in ARMS2 and CFH, indicating a genetic and pathophysiologic overlap between cCSC and AMD. Intriguingly, alleles in ARMS2 and CFH that confer risk of AMD may be protective for cCSC, and alleles in CFH that are protective for AMD confer risk for cCSC. Significant differences in allele frequencies were found among the phenotypic subgroups for several SNPs, illustrating the importance of correct clinical classification.
Keywords
CSCCCSCAMDChronic central serous chorioretinopathyRPEICGCFHSD OCTfluorescein angiographyretinal pigment epitheliumIndocyanine greenSpectral-domain optical coherence tomographyComplement factor Halternative complement pathwayage-related macular degenerationodds ratioSingle nucleotide polymorphismSNPCentral serous chorioretinopathy
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Authors
Eiko K. PhD, Myrte B. MD, Rosa L. MSc, Bjorn BSc, Jacqueline K. MD, Sascha MD, PhD, Jan E.E. MD, PhD, Carel B. MD, PhD, Anneke I. PhD, Camiel J.F. MD, PhD,