Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4032042 | Progress in Retinal and Eye Research | 2010 | 11 Pages |
Abstract
Vertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Müller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling.
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Authors
Valerie C. Fleisch, Stephan C.F. Neuhauss,