From quantitative protein complex analysis to disease mechanism

Interest in the field of cilia biology and cilia-associated diseases – ciliopathies – has strongly increased over the last few years. Proteomic technologies, especially protein complex analysis by affinity purification-based methods, have been used to decipher various basic but also disease-associated mechanisms. This review focusses on some selected recent studies using affinity purification-based protein complex analysis, thereby exemplifying the great possibilities this technology offers.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (149 K)Download as PowerPoint slideHighlights► Protein complex analysis. ► Affinity purification. ► Proteomic approach to study ciliopathies.