Comparing mfERGs with estimates of cone density from in vivo imaging of the photoreceptor mosaic using a modified Heidelberg retina tomograph

The spatial variation in central retinal function determined from mfERG was compared to co-localised measurements of cone density in two normal subjects. Individual cone cells in the parafoveal region of the retina were identified from 1° × 1° images of the photoreceptor mosaic using a modified Heidelberg retina tomograph (HRT). The variation in cone density compared well with previous histology and retinal imaging studies and was strongly linearly correlated (r = 0.98, p < 0.001) with mfERG amplitude within the central retina. Retinal function determined from mfERG amplitude appears to directly reflect the density of the cone cells in this region.