| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4034883 | Vision Research | 2010 | 6 Pages |
Abstract
Treatment of age-macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin® was the drug of interest in this study. Prototypes were manufactured using polymethylmethacrylate sheets as the reservoir material, a semi-permeable membrane for controlled delivery and silicone check valves for refilling. The device showed near zero-order release kinetics and Avastin® stability was investigated with accelerated temperature studies.
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Authors
Sarah A. Molokhia, Himanshu Sant, Jacquelyn Simonis, C.J. Bishop, R.M. Burr, Bruce K. Gale, Balamurali K. Ambati,