Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4034955 | Vision Research | 2009 | 10 Pages |
Abstract
We investigated the effect of glaucoma (GL) on nerve growth factor (NGF) presence in two brain visual areas. Rats with elevated intraocular pressure (EIOP), induced by hypertonic saline injection in the episcleral vein, were treated with eye topical application of saline or NGF. Rats were subsequently sacrificed, and brain tissues were used for immunohistochemical, biochemical, and molecular analyses. We found that GL alters the basal level of NGF and NGF receptors in brain visual centers and that NGF eye application normalized these deficits. These findings demonstrate that the reduced presence of NGF can arise due to degenerative events in retinal and brain visual areas.
Related Topics
Life Sciences
Neuroscience
Sensory Systems
Authors
Valentina Sposato, Vincenzo Parisi, Luigi Manni, Maria Teresa Antonucci, Veronica Di Fausto, Federica Sornelli, Luigi Aloe,