Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4034979 | Vision Research | 2009 | 18 Pages |
Abstract
We examined qualitatively and quantitatively in adult rat retinas the temporal degeneration of the nerve fibre layer after intra-orbital optic nerve transection (IONT) or crush (IONC). Retinal ganglion cell (RGC) axons were identified by their heavy neurofilament subunit phosphorylated isoform (pNFH) expression. Optic nerve injury induces a progressive axonal degeneration which after IONT proceeds mainly with abnormal pNFH-accumulations in RCG axons and after IONC in RGCs somas and dendrites. Importantly, this aberrant pNFH-expression pattern starts earlier and is more dramatic after IONT than after IONC, highlighting the importance that the type of injury has on the time-course of RGC degeneration.
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Authors
Guillermo Parrilla-Reverter, Marta Agudo, Francisco Nadal-Nicolás, Luis Alarcón-Martínez, Manuel Jiménez-López, Manuel Salinas-Navarro, Paloma Sobrado-Calvo, José M. Bernal-Garro, María P. Villegas-Pérez, Manuel Vidal-Sanz,