Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4035086 | Vision Research | 2008 | 8 Pages |
Abstract
The garter snake provides a unique model for in-vivo imaging of photoreceptor damage induced by laser retinal exposure. Laser thermal/mechanical retinal injury induced alterations in photoreceptor structure and leukocyte cellular behavior. Photoreceptors turned white, lost mode structure, and swelled; leukocyte activity was observed in the vicinity of photoreceptor cells. Non-thermal alterations were identified with a bio-tag for oxidative stress. Mechanisms of photoreceptor recovery and replacement were observed and evaluated for active cytoskeletal systems by using an anti-actin tag that could detect the presence of active cytoskeletal systems resident in photoreceptors as well as other retinal systems.
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Authors
H. Zwick, P. Edsall, B.E. Stuck, E. Wood, R. Elliott, R. Cheramie, H. Hacker,