Article ID Journal Published Year Pages File Type
4035564 Vision Research 2008 7 Pages PDF
Abstract

Lampreys represent the most primitive vertebrate class of jawless fish and serve as an evolutionary model of the vertebrate visual system. Transducin-α (Gαt) subunits were investigated in lamprey Petromyzon marinus in order to understand the molecular origins of rod and cone photoreceptor G proteins. Two Gαt subunits, GαtL and GαtS, were identified in the P. marinus retina. GαtL is equally distant from cone and rod G proteins and is expressed in the lamprey’s long photoreceptors. The short photoreceptor GαtS is a rod-like transducin-α that retains several unique features of cone transducins. Thus, the duplication of the ancestral transducin gene giving rise to rod transducins has already occurred in the last common ancestor of the jawed and jawless vertebrates.

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Life Sciences Neuroscience Sensory Systems
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