Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4035713 | Vision Research | 2007 | 14 Pages |
Abstract
To assess the effect of NT-4 deprivation on maturation of retinal circuitry, we investigated a mouse with targeted deletion of the gene encoding nt-4 (nt-4−/−). In particular, we studied neurons immunostained by an antibody recognizing tyrosine hydroxylase (TH), the rate limiting enzyme for dopamine (DA) synthesis. We found that TH immunopositive processes were altered in the retina of nt-4−/−. Alteration of TH immunopositive processes in nt-4−/− mice resulted in changes of DA turnover, as assessed by high-pressure liquid chromatography measurements. These findings suggest that retinal NT-4 plays a role in the morphological maturation of dopaminergic retinal cells.
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Authors
Martina Calamusa, Padmanabhan Paranji Pattabiraman, Nikita Pozdeyev, P. Michael Iuvone, Alessandro Cellerino, Luciano Domenici,