| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4035833 | Vision Research | 2006 | 11 Pages |
Abstract
We studied electrophysiological properties of cultured retinal pigment epithelial (RPE) cells from mouse and a mouse model for Norrie disease. Wild-type RPE cells revealed the expression of ion channels known from other species: delayed-rectifier K+ channels composed of Kv1.3 subunits, inward rectifier K+ channels, CaV1.3 L-type Ca2+ channels and outwardly rectifying Cl− channels. Expression pattern and the ion channel characteristics current density, blocker sensitivity, kinetics and voltage-dependence were compared in cells from wild-type and Norrie mice. Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models.
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Authors
Guido Wollmann, Steffen Lenzner, Wolfgang Berger, Rita Rosenthal, Mike O. Karl, Olaf Strauss,