Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4035850 | Vision Research | 2007 | 7 Pages |
Abstract
Robust IGF-I overexpression induces ocular angiogenesis in mice. To investigate the effect of subtle IGF-I overexpression, we examined the ocular phenotype of IGF-II promoter-driven IGF-I transgenic mice. Despite 2.5-fold elevation of IGF-I mRNA in the retina and 29 and 52% increase of IGF-I protein in the retina and aqueous humor, respectively, no ocular abnormality was observed in these transgenics. This was correlated with unaltered VEGF mRNA levels in the transgenic retina. The transgene was also associated with an attenuated laser-induced choroidal neovascularization. Differential expression levels and pattern of IGF-I gene may underlie the different retinal phenotypes in different transgenic lines.
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Authors
Wenzheng Hu, Wei Wang, Hua Gao, Jin Zhong, Weiguo Yao, Wei-Hua Lee, Ping Ye, Xiaoxi Qiao,