Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4036049 | Vision Research | 2006 | 9 Pages |
Abstract
Metarhodopsin-II is the light-excited form of rhodopsin that triggers G protein function. Metarhodopsin-II is stabilized when the N-terminus of the carboxyl (340–350) tail peptide of the α-subunit of transducin (Gtα) is crosslinked to rhodopsin cysteine 140 or the 340–350 peptide C-terminus of Gtα is crosslinked to rhodopsin cysteine 316. When the N-terminus of the peptide is coupled to C316 the MI ↔ MII equilibrium is not affected. The evidence suggests that the N-terminus of the 340–350 region of Gtα is located near C140 when transducin stabilizes metarhodopsin-II and alternative explanations are suggested for the effectiveness of the 340–350 Gtα tail peptide when bound to C316.
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Authors
Thomas E. Angel, Paul C. Kraft, Edward A. Dratz,