| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 40481 | Applied Catalysis A: General | 2013 | 4 Pages |
Abstract
A sustainable three-component reaction of indoles, aldehydes, and malononitrile in water promoted by polyethylene glycol (PEG-200) afforded 3-indole derivatives in good to excellent yields.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (136 K)Download as PowerPoint slideHighlights► A sustainable protocol for synthesis of 3-indole derivatives was established. ► Reaction of indoles, aldehydes, malononitrile was promoted by PEG-200 in water. ► The metal catalysts such as copper or indium are not required in this protocol. ► The reaction media can be reused four times without erosion of the yield. ► The target products often can be easily isolated by simple filtration.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Leilei Wang, Manna Huang, Xinhai Zhu, Yiqian Wan,