Sulfated tungstate catalyzed selective N-monoalkylation of primary amines with alcohol

We have developed an environmentally benign protocol for N-monoalkylation of primary amines with alcohols using sulfated tungstate as heterogeneous catalyst. Elimination of formation of overalkylated amines as by-products, use of alcohols as alkylating agent has resulted in high atom-economy transformation. In addition efficient, mild reaction conditions, easy product isolation and reusability of the catalyst are attractive features. The developed protocol has been successfully applied for N-monoalkylation of aromatic as well aliphatic amines with different alcohols.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (87 K)Download as PowerPoint slideHighlights► Sulfated tungstate is mildly acidic, stable, eco-friendly heterogeneous catalyst. ► The catalyst is easy to prepare and well characterized. ► Efficient for selective N-monoalkylation of primary amines. ► The catalyst can be easily recovered and recycled several times.