| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 40580 | Applied Catalysis A: General | 2013 | 6 Pages |
The Suzuki–Miyaura coupling reaction is one of the most important synthetic catalytic reactions developed in the 20th century. However, the use of toxic organic solvents for this reaction still poses a scientific challenge and is an aspect of economical and ecological relevance. The use of water as a reaction medium overcomes this issue. In the present work, we described efficient Suzuki coupling reactions in water, without any phase transfer reagents and it is possible to couple challenging substrates like aryl chlorides. Notably, this protocol also works with ultra-low loading of catalyst with high turnover numbers.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (64 K)Download as PowerPoint slideHighlights► The natural phosphate-supported palladium can provide a suitable catalyst for Suzuki coupling reactions. ► This heterogeneous catalyst displayed high catalytic activity for Suzuki coupling reactions. ► This catalyst can be simply recovered and reused without any significant loss of catalytic activity. ► No leaching was observed of the catalyst. ► The novelty of the system lies in its low cost and availability of the solid support.
