Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4079113 | Operative Techniques in Orthopaedics | 2010 | 9 Pages |
Abstract
Fibrosis is the result of an excessive amount of fibrous connective tissue deposited into the extracellular matrix space of damaged tissues from injury or disease. Collagens, particularly types I and III are the main constituents of the fibrotic scar tissue as well as a mixture of fibrotic cells. Fibrotic tissue will develop chronic healing problems severely resulting in tissue/organ dysfunction. More attention needs to be given to the fibrotic differentiation and related effects in bioengineered tissues. The current review provides an update on the mechanism behind fibrosis formation as well as technical measurements and preventions.
Related Topics
Health Sciences
Medicine and Dentistry
Orthopedics, Sports Medicine and Rehabilitation
Authors
Xiaodong PhD, Ian H. BS, Thomas J. PhD, Yong MD, PhD,