| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 40887 | Applied Catalysis A: General | 2012 | 9 Pages |
Pd(II) Xantphos or Xantphos chalcogenide complexes with general folmula [PdCl2(X∩X)] (where X = P, O, S or Se) were synthesized by the addition of corresponding ligands to [PdCl2(COD)] (COD = 1,5-cyclooctadiene). Prepared Complexes [PdCl2(Xantphos)] and [PdCl2(Xantphos = S)] showed distorted square planar geometries, from X-ray crystallographic analysis. All of the prepared complexes showed activity toward intermolecular hydroamination of isoprene with a variety of secondary amines. Complete conversion (∼100%) of pyrrolidine was observed using Pd–Xantphos as catalysts. Hydroamination reactions exhibited regioselectivity when crowded secondary amines were used.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (118 K)Download as PowerPoint slideHighlights► Pd–Xantphos complexes are potent isoprene hydroamination catalysts. ► An efficient synthesis of pharmaceutically important amines could be achieved. ► Amines with high steric hindrance yield 4-(3-methylbut-2-enyl) amines before reduction.
