| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 40922 | Applied Catalysis A: General | 2012 | 9 Pages |
Gold(III) chloride (HAuCl4·3H2O) in PEG 400 was found to be an efficient catalytic system for the synthesis of biologically important functionalized spirochromene derivatives via one-pot three-component reaction of isatins/acenaphthoquinone, active methylene compounds and cyclic 1,3-diketones/4-hydroxycoumarin. A new catalytic system, recyclability of reaction medium, little reaction times and excellent yields with easy workup render this protocol more attractive and economically viable.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (278 K)Download as PowerPoint slideHighlights► Eco-friendly method for the synthesis of functionalized spirochromenes. ► Gold(III) chloride (HAuCl4·3H2O) is used as soft carbophilic Lewis acid catalyst. ► Recyclability of polyethylene glycol (PEG). ► Multicomponent reaction. ► This protocol is green and advantageous with high yields and less reaction time.
