Detecting Thrombophilia, Hypofibrinolysis and Reduced Nitric Oxide Production in Osteonecrosis

Gene mutations leading to thrombophilia, hypofibrinolysis, and reduced nitric oxide production are risk factors for osteonecrosis. The importance of the diagnosis of thrombophilia-hypofibrinolysis in idiopathic osteonecrosis lies in the potential to stop the progression of osteonecrosis when enoxaparin is started at Ficat stages I or II before irreversible segmental collapse of the head of the femur.