| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4103287 | American Journal of Otolaryngology | 2015 | 8 Pages |
ObjectiveWe aim to assess the correlation of tumor and nodal staging to survival in pT3N + and T4aN0 laryngeal cancer with subgroup analysis within stage IVa (pT4N0 and pT3N2).Study designRetrospective cohort study with systematic review of the literature.SettingHotel Dieu de France University Hospital (tertiary referral center).Subjects and methodsLaryngeal cancer patients’ registries were reviewed from 1998 to 2012 selecting pT3N + and pT4aN0 patients treated by primary total layngectomy. Overall survivals were compared using Log rank and Kaplan–Meier analysis. A systematic review was performed by 2 reviewers including all the articles reporting the outcome of these categories of patients. Online databases, including PubMed and EMBASE, were used. Reference sections of identified studies were examined for additional articles.ResultsThirteen T3N + patients and 19 T4aN0 patients treated by primary total laryngectomy were included. Five-year overall survival for T3N +, T3N2 and T4aN0 was respectively 33%, 32.1% and 73.7%. Due to the small sample, the difference was not significant.The systematic review revealed three articles reporting overall survival outcome for the T4N0 group and 6 articles for the T3N +. At 5 years, the survival ranged from 62.5% to 73% in T4N0 and from 32.2% to 77% in T3N +.ConclusionIn advanced stage laryngeal cancer, T4aN0 tends toward a better survival than T3N + especially when compared to T3N2 although they are grouped in the same TNM stage IVa.
