Efficacy of tobramycin aerosol in nasal polyposis

ContextTreatment of infected nasal polyposis.Material and methodsMulticenter interventional prospective double-blind randomized study with matched groups: treatment with tobramycin aerosol versus isotonic saline aerosol. The study population included 55 patients: 23 receiving isotonic saline aerosol and 32 receiving tobramycin. A novel device (Easynose®) was used with an original principle limiting pulmonary deposition and ensuring homogeneous peripheral deposition in the nasal cavities.ObjectivesThe principal objective was to compare bacteriological eradication between tobramycin 150 mg/3 ml versus isotonic saline, both administered by nebulization via the Easynose® device.Results and conclusionTobramycin aerosol administered via the Easynose® device showed significantly better bacteriological eradication than isotonic saline.