The effect of Hirudoid on random skin-flap survival in rats

SummaryBackgroundOne of the main fields of research in flap surgery is to increase the viability of flaps. Many materials have been tested for this purpose. This study shows that topical application of Hirudoid, an organoheparinoid, increases flap survival of dorsal flaps in rats.MethodsHirudoid was used topically every day in eight of 16 rats in which 10 × 3-cm dorsal flaps were prepared. The flaps were taken for analysis on the 10th day. Analysis of the flaps was performed using digital measurement and scintigraphy.ResultsAnalysis revealed that the flap necrosis area was smaller in the Hirudoid group compared to the control group. In addition, the area exhibiting radioactive uptake in scintigraphy was greater in the treatment group.ConclusionTopical administration of Hirudoid may significantly improve flap survival.