Article ID Journal Published Year Pages File Type
4124797 Otolaryngology - Head and Neck Surgery 2010 6 Pages PDF
Abstract
We have characterized the early-phase mRNA expression profiles of the major mediators of radiation-induced fibrosis. Smad3 siRNA effectively abrogated the elevation of Col1A1, TGF-β, TIMP-1, and MMP-2. IL-13 and TNF-α were unaffected by Smad3 silencing and appear to be minor regulators in fibrosis. These findings suggest a therapeutic rationale for Smad3 silencing in vivo.
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Health Sciences Medicine and Dentistry Otorhinolaryngology and Facial Plastic Surgery
Authors
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