Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4124797 | Otolaryngology - Head and Neck Surgery | 2010 | 6 Pages |
Abstract
We have characterized the early-phase mRNA expression profiles of the major mediators of radiation-induced fibrosis. Smad3 siRNA effectively abrogated the elevation of Col1A1, TGF-β, TIMP-1, and MMP-2. IL-13 and TNF-α were unaffected by Smad3 silencing and appear to be minor regulators in fibrosis. These findings suggest a therapeutic rationale for Smad3 silencing in vivo.
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Authors
Judy W. MD, Richard A. MD, Cristian D. Valenzuela, Phuong D. MD, John P. MD, Benjamin R. MD, Stephen M. MD, Pierre B. MD,