Endométrite chronique pseudolymphomateuse

Chronic endometritis is a rare entity characterized by an endometrial plasmocytic infiltrate. The lymphoid infiltrate may be abundant and simulate a lymphoma of the uterus. We report two cases of lymphoma-like lesions of the endometrium in two postmenopausal women of 79 and 89 year-old, who presented with abundant vaginal discharge. Ultrasound examination revealed in both cases an intrauterin polypoid lesion. Histologically, a predominantly plasmocytic infiltrate was seen in the endometrium destroying endometrial glandes and extending into the superficial myometrium, in the first case. Immunohistochemical study showed a polymorphic lymphoid infiltrate with a predominance of T cells. Molecular study revealed a polyclonal B cell population, distinguishing the lesion from a marginal zone lymphoma. Lymphoma-like lesions of female genital tract must be distinguished from malignant lymphoma that rarely occurs in this site.