Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4129254 | Annales de Pathologie | 2008 | 9 Pages |
Abstract
The identification of fusion genes provides new insights into the initial mechanisms of molecular events implicated in the tumorigenesis of prostate cancer. The presence of TEMPRSS2-ETS fusion in up to half of all human prostate cancers makes it perhaps the most common genetic rearrangement in human epithelial tumors. Some data suggest that TMPRSS2-ERG fusion prostate cancers have a more aggressive phenotype which may affect cancer progression and outcome in localized tumors treated with prostatectomy. This discovery should pave the way towards future targeted therapies.
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Authors
Vincent Molinié, Philippe Beuzeboc, Wafa K. Mahjoub,